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Illumina Ventures Labs

At Illumina, we’re committed to unlocking the power of the genome, and we know we can’t do it alone.

San Francisco, CA, USA

Description

Illumina Ventures is an independently-managed, early-stage venture capital firm focused on genomics, precision health, and life science innovation. It was launched in 2016 in Foster City, California in strategic partnership with Illumina, Inc., the global leader in DNA sequencing, though the VC operates independently and raises capital from multiple limited partners. 

Illumina Ventures also operates Illumina Ventures Labs, an early-stage company creation and acceleration engine that provides capital, mentorship, lab resources, and sequencing infrastructure to emerging genomics startups. 

Specific Funding Stage
Pre-Seed / Seed (Core Focus)

  • Illumina Ventures primarily invests in pre-seed and seed stage companies pioneering applications of genomics and precision health. 

  • Through Illumina Ventures Labs, it engages even earlier via hybrid cash + in-kind support, technical mentorship, and access to fully equipped genomics labs before traditional seed rounds. 

Early Growth / Series A (Follow-On)

  • Illumina Ventures also participates in later early rounds (e.g., Series A) as portfolio companies grow, often syndicating with other institutional life sciences investors. 

Investment Amount and Typical Equity
Check Size

  • Reported allocation per investment typically ranges from around $500 K up to ~$10 M+ depending on stage, deal structure, and follow-on participation. 

Equity Taken

  • Illumina Ventures does not publicly disclose a fixed equity target. Like most institutional VCs, ownership is negotiated deal-by-deal based on valuation and financing dynamics. 

  • When participating via Illumina Ventures Labs, early support often combines capital with in-kind sequencing access, which may affect overall equity terms in ways tailored to each startup’s needs. 

Implied Ownership (Contextual, Not Published)

  • Typical early-stage VC outcomes result in minority, non-controlling stakes, with exact percentages depending on round size, valuation, and co-investors.

Equity Structure
  • Investments use standard venture instruments appropriate for early stages (e.g., priced preferred equity, SAFEs, or notes depending on round structure).

  • Equity allocations are negotiated with founders and co-investors; Illumina Ventures emphasizes cash + in-kind technical support (e.g., lab access, sequencing) particularly through its Lab program, which can effectively extend runway and de-risk early translational work. 

Application / Submission Method
Submission Method

  • Illumina Ventures primarily sources opportunities through warm introductions, founder outreach, and in part via Illumina Ventures Labs relationships with startups in genomics and precision health.

  • Intro is preferred over cold outreach

Interaction

  • Startups that engage with Illumina Ventures Labs gain structured interaction via monthly mentorship sessions, sequencing support, and collaboration with technical teams, which also serves as de-facto diligence before formal investment. 

Eligibility

Sector Focus
Illumina Ventures is deeply specialized in:

  • Genomics and precision medicine technologies

  • Life science tools and platforms

  • Clinical diagnostics and testing technologies

  • Therapeutics enabled by genomic insights

  • Health tech and digital solutions adjacent to genomics innovations 

Stage

  • Pre-seed and seed are primary; follow-on into Series A and early growth for portfolio successes. 

Geography

  • Primarily U.S. and Europe with global deal flow through Labs and partner networks. 

Team Profile

  • Founders with domain expertise in biology, genomics, diagnostics, and health sciences, often with advanced technical or scientific backgrounds and deep domain differentiation.

Process

  1. Intro / Outreach: Founders make contact (often via warm intro).

  2. Initial Evaluation: Assessment of team quality, unmet needs, and genomics relevance.

  3. Labs Engagement (if applicable): Early operational collaboration through Illumina Ventures Labs serves as ongoing diligence. 

  4. Investment Consideration: Partners evaluate structured term negotiations suited to stage and technical readiness.

  5. Follow-On Review: Progress post-initial investment is reviewed for potential follow-on capital.

What an Applicant can Obtain

  • Early Capital: Meaningful early funding (~$500K to $10M+ across stages). 

  • Technical Support: Access to Illumina Ventures Labs’ genomics labs, sequencing platforms, and technical expertise for early product development. 

  • Mentorship & Industry Access: Guidance from experienced life sciences operators and investors.

  • Network & Follow-On Funding: Connections to co-investors and later financing opportunities with venture partners.